mood: recent publications

All articles where mood is mentioned

additudemag.com
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LSD, MDMA, Magic Mushrooms Clinical Trial Guidelines Released by FDA
July 7, 2023The Food and Drug Administration (FDA) has issued its first-ever draft guidance for clinical trials of psychedelic drugs to treat conditions including depression, mood disorders, anxiety, post-traumatic stress disorder, and substance use disorder.The guidance aims to address the unique challenges inherent in testing “classic psychedelics,” such as psilocybin (magic mushrooms) and lysergic acid diethylamide (LSD), and “entactogens” or “empathogens,” such as methylenedioxymethamphetamine (MDMA) for treating psychiatric conditions that failed to respond to other therapies. The FDA recommends clinical trial considerations regarding subject safety, data collection, manufacturing controls, and drug application requirements.Ultimately, “the goal is to help researchers design studies that will yield interpretable results that will be capable of supporting future drug applications,” said Tiffany Farchione, M.D., director of the Division of Psychiatry in the FDA’s Center for Drug Evaluation and Research, in a statement last month.In February 2022, researchers from Johns Hopkins Medicine reported that psilocybin-assisted therapy for major depressive disorder produced antidepressant effects up to 12 months after treatment.1Ari Tuckman, Psy.D., and Stephanie Sarkis, Ph.D., recently told ADDitude that using very low (micro) doses of psychedelics, such as LSD and psilocybin is gaining renewed attention as a treatment for anxiety and depression.
additudemag.com
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191
[Self-Test] PMDD Test: Premenstrual Dysphoric Disorder Symptoms
Premenstrual dysphoric disorder (PMDD) is a serious but treatable condition that affects 5.5% of people who menstruate.1 A severe version of premenstrual syndrome (PMS), PMDD is a mood disorder characterized by marked sadness, irritability, depressed mood, and/or anger, and other behavioral and physical symptoms that appear during the luteal phase of the menstrual cycle (about two weeks before menses) and remit within a few days of menstruation.2 The symptoms of PMDD cause significant distress and functional impairment.It’s not a requirement that PMDD symptoms appear leading up to every period, though symptoms must have occurred in most of the menstrual cycles during the past year. A diagnosis of PMDD, per the DSM-5, should also be confirmed by tracking daily symptoms during at least two menstrual cycles.PMDD often co-occurs with other psychiatric disorders, including major depressive disorder (MDD) and anxiety disorder.34 Individuals with PMDD are also at greater risk for suicide and suicidal behavior.3 Research on PMDD and attention deficit hyperactivity disorder (ADHD) is limited, though a 2021 study of 209 women with ADHD found that more than 45% of them reported having symptoms suggestive of PMDD.5In a recent ADDitude survey, two-third of women surveyed said they experienced PMS and/or PMDD.
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