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Gene Screenings Hold Disease Clues, but Unexplained Anomalies Often Raise Fears

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By Christina Bennett When her gynecologist recommended genetic testing, Mai Tran was reluctant. “I didn’t really want to do it,” recalled Tran, who had just turned 21 and was living in New York City, “but she kept on emailing me about it and was really adamant that I do it.” Tran knew she had an elevated risk of developing breast cancer because of her family history — her mother died of the disease and a maternal aunt was diagnosed and survived.

Given this, she planned to follow the standard recommendations to begin breast cancer screenings at an early age. But she feared that if the testing her doctor was suggesting revealed a genetic variation known to cause breast cancer, she would have to decide whether to have her breasts surgically

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