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5 Things You Should Know About Progressive Familial Intrahepatic Cholestasis

Family people life feelings
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Progressive familial intrahepatic cholestasis (PFIC) is a progressive disease of the liver in which liver cells are less able to secrete bile.

A buildup of bile leads to liver disease and liver failure resulting in the need for transplant. The disease is genetic and runs in families.

It occurs in about 1 in 50,000 to 1 in 100,000 live births and is considered a rare disease. There are three types of PFIC — PFIC1, PFIC2 and PFIC3.

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